Comparative Study of Acute Phase Proteins in Case of Anemia of Chronic Disease (acd) and Iron Deficiency Anemia (ida) and Its Relationship with Erythropoietin

Acute phase proteins play a significant role in anemia of chronic disease and thought to be beneficial in maintain homeostasis. In both the condition, anemia of chronic disease as well as iron deficiency anemia alteration in iron homeostasis takes place. The study includes patients of pulmonary tuberculosis patients (ACD), Iron deficiency anemia (IDA) patients and control subjects. Serum CRP, Serum Haptoglobin (HPT), SerumTransferrine (TRF) and Serum Erythropoietin (EPO) levels were estimated in both the study groups. These values were compared to control subjects. The result of the present study reveals that alteration of acute phase protein takes place in the study groups which leads to disturbance in iron metabolism, resulting anemia. However the changing pattern in Acute Phase Proteins in Anemia of Chronic Disease (ACD) and Iron Deficiency Anemia is different ( in ACD, Serum level of CRP, HPT,FRT increases whereas serum level of TRF decreases. But in case of IDA Serum level of CRP and TRF increases whereas serum level of FRT decreases and there was no significant change (p > 0.05) observed in Serum Haptoglobin level, when this value was compared with the value of controls).